1- adrenoceptors were divided first into α and β, then subdivided
into α1/α2 and β1/β2. Many other useful receptor classifications,
including those of cholinoceptors, histamine receptors, serotonin
receptors, benzodiazepine receptors, glutamate receptors
and others have been proposed on a similar basis.
2- dose ratio is If a dose (C) of agonist causes a defined effect when
administered alone, then the dose (C ) needed to produce the
same effect in the presence of antagonist .
3- Bioavailability of a drug is measuring concentration vs. time
curves following administration of the preparation via its
intended route (e.g. orally) and of the same dose given intravenously
(i.v.).
4- prodrug is One approach to improving absorption or distribution to a relatively
inaccessible tissue (e.g. brain) is to modify the drug
molecule chemically to form a compound that is better
absorbed and from which active drug is liberated after absorption.
5- Metronidazole is well absorbed when administered
rectally, and is less expensive than intravenous preparations.
6-
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